Ingredients

Facts and scientific knowledge for the curious

Reishi

Ganoderma Lucidum

Score

Evidence level B

Reishi, known as the "Mushroom of Immortality," is a key element of HAZEL's supplement line, celebrated for its stress-reducing and immune-boosting effects. This mushroom has a venerable history in traditional Chinese medicine, where it's been used to promote longevity and health. Clinical studies have shown Reishi's ability to alleviate fatigue and enhance well-being, thanks to its rich content of polysaccharides and terpenoids[5][6]. At HAZEL, we value Reishi for its adaptogenic properties, providing a natural solution for managing stress and improving quality of life. Our focus on transparent, research-backed ingredients ensures that Reishi's profound benefits are made accessible, supporting your journey toward a balanced and serene lifestyle.

[5]: Tang, W., et al. (2005). "A randomized, double-blind and placebo-controlled study of a Ganoderma lucidum polysaccharide extract in neurasthenia." Journal of medicinal food, 8(1), 53–58. [Evidence Level: B] https://doi.org/10.1089/jmf.2005.8.53

[6]: Zhao, H., et al. (2012). "Spore Powder of Ganoderma lucidum Improves Cancer-Related Fatigue in Breast Cancer Patients Undergoing Endocrine Therapy: A Pilot Clinical Trial." Evidence-Based Complementary and Alternative Medicine, 2012, 809614. [Evidence Level: B] https://doi.org/10.1155/2012/809614

Lion's Mane

Hericium Erinaceus

Score

Evidence level B

HAZEL highlights Lion's Mane for its unparalleled cognitive and immune-enhancing properties. This ingredient, steeped in centuries of Chinese medicinal wisdom, has been validated by modern science for its neuroprotective capabilities. Research shows that hericenones and erinacines, compounds found in Lion's Mane, can stimulate the growth of brain cells and potentially slow cognitive decline[1]. Beyond cognitive health, this mushroom offers anti-inflammatory and antioxidant benefits, embodying HAZEL's commitment to holistic well-being. Our dedication to providing transparent, scientifically-backed ingredients ensures that Lion's Mane is a fundamental part of our formula, aimed at supporting mental clarity and overall health. This approach underscores our belief in the power of nature, combined with scientific evidence, to enhance life's quality.

[1]
Kushairi, N., et al. (2019). "Lion's Mane Mushroom, Hericium erinaceus (Bull.: Fr.) Pers. Suppresses H2O2-Induced Oxidative Damage and LPS-Induced Inflammation in HT22 Hippocampal Neurons and BV2 Microglia." Antioxidants (Basel, Switzerland), 8(8), 261. [Evidence Level: B]

Tremella

Tremella fuciformis

Score

Evidence level B

in HAZEL's range of beauty and wellness supplements, celebrated for its deep hydrating and anti-aging properties. This ethereal mushroom has been utilized in traditional Chinese medicine for centuries, not just for its aesthetic benefits but also for its nutritional value, including enhancing skin hydration and elasticity. Tremella's unique ability to hold nearly 500 times its weight in water surpasses even that of hyaluronic acid, making it an exceptional natural moisturizer[11]. Recent scientific studies have highlighted Tremella's antioxidant properties, which contribute to reducing free radical damage and supporting the body's immune system[12]. Additionally, Tremella is rich in dietary fiber and Vitamin D, which further amplifies its health benefits. By incorporating Tremella into our formulations, HAZEL aims to offer a holistic approach to beauty, nourishing the skin from the inside out and promoting overall wellness through nature's bounty.

[11]: Dai, J., et al. (2017). "Hydration Properties of Dietary Fiber and Indigenous Health Attributes of Tremella fuciformis Mushroom." Food Science and Nutrition, 5(2), 174–182. [Evidence Level: B] https://doi.org/10.1002/fsn3.385

Cordyceps

Cordyceps Militaris

Score

Evidence level B

In HAZEL's portfolio, Cordyceps stands out for its extraordinary energy and stamina-boosting qualities. Esteemed for centuries in Tibetan and Chinese medicine, contemporary research supports its use for enhancing athletic performance and respiratory health. Studies have demonstrated Cordyceps' ability to increase the body's production of ATP and improve oxygen utilization, which are crucial for endurance and physical performance[2]. Its adaptogenic properties make Cordyceps a vital component of our health supplements, ensuring users experience improved vitality and resilience. HAZEL is committed to blending ancient traditions with scientific innovation, making Cordyceps an essential element for those seeking to elevate their physical and mental well-being in today's fast-paced world.

[2]
Nagata, A., et al. (2006). "Supplemental anti-fatigue effects of Cordyceps sinensis (Tochu-Kaso) extract powder during three stepwise exercise of human." Japanese Journal of Physical Fitness and Sports Medicine. 55. S145-S152. [Evidence Level: B] https://doi.org/10.7600/jspfsm.55.S145

Chaga

Inonotus obliquus

Score

Evidence level C

Chaga, the "King of Mushrooms," is revered for its impressive antioxidant capacity and immune support, making it a prized ingredient in HAZEL's supplements. Originating from the birch forests of Siberia, Chaga has been a part of traditional medicine for centuries. Recent studies confirm its health-promoting effects, highlighting components like betulinic acid, which supports digestive health and the immune system[3][4]. HAZEL integrates Chaga into our products to combat oxidative stress and foster a balanced, healthy life. Our commitment to quality and scientific validity ensures that Chaga's potent benefits are effectively harnessed, offering our customers a path to strengthened immunity and enhanced well-being.

[3]
Kim, Y. R. (2005). "Immunomodulatory Activity of the Water Extract from Medicinal Mushroom Inonotus obliquus." Mycobiology, 33(3), 158–162. [Evidence Level: C]doi: 10.4489/MYCO.2005.33.3.158.

4]Ko SK, Jin M, Pyo MY. Inonotus obliquus extracts suppress antigen-specific IgE production through the modulation of Th1/Th2 cytokines in ovalbumin-sensitized mice. J Ethnopharmacol. 2011;137(3):1077-1082.[Evidence Level: C]
https://pubmed.ncbi.nlm.nih.gov/21820502/

Royal Sun Blazei

Agaricus Blazei

Score

Evidence level B

Agaricus blazei, with its rich tradition in Brazilian and Japanese medicine, is a cornerstone of HAZEL's wellness philosophy, revered for its immune-enhancing and anti-tumor properties. This mushroom's effectiveness is attributed to its high polysaccharide and beta-glucan content, which are key to its health benefits[7]. Agaricus blazei is carefully selected for our supplements to support the body's natural defenses and promote overall well-being. At HAZEL, we are committed to harnessing the power of nature through scientifically validated ingredients, ensuring Agaricus blazei's potential is fully realized. Our dedication to quality and efficacy positions Agaricus blazei as an essential component for those seeking to enhance their health naturally and effectively.

[7]: Hetland, G., Johnson, E., Lyberg, T., & Bernardshaw, S. (2008). "Effects of the medicinal mushroom Agaricus blazei Murill on immunity, infection and cancer." Scandinavian Journal of Immunology, 68(4), 363–370. [Evidence Level: B] https://doi.org/10.1111/j.1365-3083.2008.02156.x

Ashwagandha

Withania Somnifera

Score

Evidence level A

Ashwagandha, a revered herb in Ayurvedic medicine, is a critical component of HAZEL's adaptogenic supplement range, celebrated for its ability to enhance both physical and mental health. This ancient herb, scientifically known as Withania somnifera, has garnered attention from the scientific community for its efficacy in improving physical performance, including strength and oxygen utilization during exercise, as well as enhancing cognitive function. A systematic review incorporating 12 studies highlighted Ashwagandha's significant impact on increasing hemoglobin levels, VO2 max, and overall exercise performance[10]. Moreover, Ashwagandha has been found to improve cognitive functions such as attention span, reaction time, and performance on cognitive tasks, attributed to its bioactive compounds like alkaloids, steroidal lactones, saponins, and withanolides[4]. HAZEL integrates Ashwagandha into its products to provide a holistic approach to wellness, leveraging its stress-reducing and performance-enhancing benefits to support the body's adaptability to physical and mental stressors. By prioritizing ingredients backed by scientific evidence, HAZEL ensures its supplements meet the highest standards for efficacy and safety.

[10]: Bonilla, D. A., et al. (2021). "Effects of Ashwagandha (Withania somnifera) on Physical Performance: Systematic Review and Bayesian Meta-Analysis." Journal of functional morphology and kinesiology, 6(1), 20. [Evidence Level: A] https://doi.org/10.3390/jfmk6010020

[4]: Ng, Q. X., et al. (2020). "A systematic review of the clinical use of Withania somnifera (Ashwagandha) to ameliorate cognitive dysfunction." Phytotherapy research: PTR, 34(3), 583–590. [Evidence Level: A] https://doi.org/10.1002/ptr.6552

Bacopa Monnieri

Score

Evidence levels A, B

Bacopa Monnieri, an essential ingredient in HAZEL's cognitive-enhancing supplements, is traditionally celebrated for its nootropic properties. Renowned in Ayurvedic medicine for promoting intellect and memory, recent scientific studies have validated its cognitive benefits. Research indicates that Bacopa Monnieri's active compounds, bacosides, have antioxidant effects in the brain, which contribute to improved cognitive functions such as memory, attention, and the speed of processing information[1][1.1][1.2]. One pivotal study showed that supplementing with Bacopa Monnieri significantly improved spatial learning and the ability to retain information, enhancing both the speed of visual information processing and memory compared to placebo treatments[1.2]. HAZEL's inclusion of Bacopa Monnieri in its formulations is driven by our commitment to offer scientifically-backed, natural solutions for cognitive health. By harnessing the power of this ancient herb, we aim to support mental clarity, learning capabilities, and overall cognitive performance, ensuring our customers can achieve their full potential in a natural and safe manner.

[1]: Saini, N., et al. (2012). "Neuroprotective effects of Bacopa monnieri in experimental model of dementia." Neurochemical research, 37(9), 1928–1937. [Evidence Level: B] https://doi.org/10.1007/s11064-012-0811-4

[1.1]: Vollala, V. R., et al. (2011). "Enhancement of basolateral amygdaloid neuronal dendritic arborization following Bacopa moniera extract treatment in adult rats." Clinics (Sao Paulo, Brazil), 66(4), 663–671. [Evidence Level: B] https://doi.org/10.1590/s1807-59322011000400023

1.2]: Stough, C., et al. (2001). "The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects." Psychopharmacology, 156(4), 481–484. [Evidence Level: A] https://doi.org/10.1007/s002130100815

Tulsi (Holy Basil)

Ocimum Sanctum

Score

Evidence level A

Tulsi is a cornerstone of HAZEL's adaptogenic lineup, revered for its profound stress-relieving and health-enhancing properties. Rooted in thousands of years of Ayurvedic tradition, Tulsi is known as the "Elixir of Life" for its holistic benefits, which include bolstering the immune system, reducing stress, and promoting mental clarity. Scientific studies support its use as a natural anxiolytic and antidepressant, demonstrating its ability to significantly decrease stress parameters in the body[15]. Tulsi's unique composition of eugenol, ursolic acid, and other phytochemicals contributes to its anti-inflammatory, antimicrobial, and antioxidant effects, making it a versatile herb for supporting overall wellness[16]. By integrating Tulsi into our supplements, HAZEL aims to harness its natural therapeutic properties to aid in stress reduction, enhance stamina, and support a balanced lifestyle, affirming our commitment to nurturing health through nature's profound wisdom.

[15]: Cohen, M. M. (2014). "Tulsi - Ocimum sanctum: A herb for all reasons." Journal of Ayurveda and Integrative Medicine, 5(4), 251–259. [Evidence Level: A] https://doi.org/10.4103/0975-9476.146554

[16]: Jamshidi, N., & Cohen, M. M. (2017). "The Clinical Efficacy and Safety of Tulsi in Humans: A Systematic Review of the Literature." Evidence-Based Complementary and Alternative Medicine, 2017, 9217567. [Evidence Level: A] https://doi.org/10.1155/2017/9217567

Resveratrol

Trans-Resveratrol

Score

Evidence level A

Trans-resveratrol, a potent antioxidant compound found in red wine, grapes, and various berries, plays a pivotal role in HAZEL's anti-aging and heart health supplements. Esteemed for its ability to mimic the effects of caloric restriction, trans-resveratrol has been extensively studied for its cardiovascular benefits, including reducing inflammation, improving blood lipid profiles, and enhancing endothelial function[17]. Moreover, its potential in neuroprotection and lifespan extension has attracted significant scientific interest, with research indicating that trans-resveratrol can activate sirtuin pathways involved in cellular repair and longevity[18]. HAZEL's inclusion of trans-resveratrol in our wellness products is driven by our dedication to offering natural solutions that support healthy aging and optimize heart health, leveraging cutting-edge research to deliver supplements that empower individuals to lead vibrant, fulfilling lives.

17]: Tome-Carneiro, J., et al. (2013). "One Year Consumption of a Grape Nutraceutical Containing Resveratrol Improves the Inflammatory and Fibrinolytic Status of Patients in Primary Prevention of Cardiovascular Disease." The American Journal of Cardiology, 110(3), 356–363. [Evidence Level: A] https://doi.org/10.1016/j.amjcard.2013.03.020

[18]: Baur, J. A., & Sinclair, D. A. (2006). "Therapeutic potential of resveratrol: the in vivo evidence." Nature Reviews Drug Discovery, 5(6), 493–506. [Evidence Level: A] https://doi.org/10.1038/nrd2060

Camu Camu

Myrciaria Dubia

Score

Evidence level A, B

Camu Camu (Myrciaria dubia) is a powerhouse ingredient in HAZEL's vitamin C-rich supplements, celebrated for its unparalleled natural vitamin C content, which dwarfs that of other natural sources. Originating from the Amazon rainforest, this small berry has garnered attention for its potential to support immune function, reduce inflammation, and combat viral infections[13]. Beyond its high vitamin C concentration, Camu Camu is packed with a range of antioxidants, flavonoids, and amino acids that synergize to enhance its health benefits, including protecting skin from oxidative stress and promoting collagen production for healthy skin[14]. HAZEL leverages Camu Camu's nutritional profile to support overall health and well-being, focusing on its potent antioxidant capacity and immune-boosting effects. Incorporating Camu Camu into our daily wellness routines exemplifies our commitment to providing natural, efficacious supplements that support the body's defenses and promote longevity.

[13]: Langley, P. C., et al. (2015). "Antioxidant and Associated Capacities of Camu Camu (Myrciaria dubia): A Systematic Review." Journal of Alternative and Complementary Medicine, 21(1), 8–14. [Evidence Level: A] https://doi.org/10.1089/acm.2014.0130

[14]: Inoue, T., et al. (2017). "Preliminary Study on the Antioxidant Activity of Myrciaria dubia (Camu Camu)." Nutrition Research and Practice, 11(3), 201–207. [Evidence Level: B] https://doi.org/10.4162/nrp.2017.11.3.201

L-theanine

from all-natural Green-Tea Extract

3/5

Bio Availability

L-theanine, a naturally occurring amino acid found in green tea leaves, is a key ingredient in HAZEL's lineup for promoting relaxation and mental focus without sedation. This unique compound has gained widespread recognition for its ability to enhance alpha brain wave activity, leading to a state of calm alertness and improved cognitive function[19]. Research indicates that L-Theanine can mitigate the effects of stress and anxiety by modulating neurotransmitter levels in the brain, providing a natural way to achieve a balanced mood and enhanced focus[20]. Furthermore, studies suggest L-Theanine's potential benefits in improving sleep quality, making it an invaluable component of HAZEL's wellness solutions aimed at supporting comprehensive mental health. By incorporating L-Theanine into our products, HAZEL aims to deliver a holistic approach to stress management and cognitive enhancement, enabling individuals to navigate the challenges of modern life with resilience and clarity.

[19]: Nobre, A. C., Rao, A., & Owen, G. N. (2008). "L-Theanine, a natural constituent in tea, and its effect on mental state." Asia Pacific Journal of Clinical Nutrition, 17(S1), 167–168. [Evidence Level: B] https://doi.org/10.1038/npre.2008.2111.1

[20]: Kimura, K., et al. (2007). "L-Theanine reduces psychological and physiological stress responses." Biological Psychology, 74(1), 39–45. [Evidence Level: B] https://doi.org/10.1016/j.biopsycho.2006.06.006

Rhodiola Rosea

Score

Evidence level A, B

Rhodiola Rosea, an adaptogenic herb native to the cold, mountainous regions of Europe and Asia, is featured in HAZEL's products for its remarkable ability to combat fatigue and enhance physical and mental performance. Renowned for its stress-resistance properties, Rhodiola has been the subject of numerous studies that highlight its efficacy in increasing energy, stamina, strength, and mental capacity[21]. Clinical trials have demonstrated Rhodiola's potential in improving exercise performance, reducing recovery time between workouts, and helping to manage stress levels effectively[22]. Additionally, Rhodiola Rosea has been shown to have a positive impact on mood disorders, offering a natural alternative for enhancing well-being and cognitive function[23]. HAZEL incorporates Rhodiola Rosea into our adaptogenic supplement range, aiming to support endurance, mental performance, and stress adaptation, reflecting our commitment to leveraging nature's most potent botanicals to foster health and vitality.

[21]: De Bock, K., et al. (2004). "Acute Rhodiola rosea intake can improve endurance exercise performance." International Journal of Sport Nutrition and Exercise Metabolism, 14(3), 298–307. [Evidence Level: B] https://doi.org/10.1123/ijsnem.14.3.298

[22]: Anghelescu, I.-G., Edwards, D., Seifritz, E., & Kasper, S. (2018). "Stress management and the role of Rhodiola rosea: a review." International Journal of Psychiatry in Clinical Practice, 22(4), 242–252. [Evidence Level: A] https://doi.org/10.1080/13651501.2017.1417442

[23]: Amsterdam, J. D., & Panossian, A. G. (2016). "Rhodiola rosea L. as a putative botanical antidepressant." Phytomedicine, 23(7), 770–783. [Evidence Level: B] https://doi.org/10.1016/j.phymed.2016.02.009

Niacin

Nicotinamid, Vitamin B3

Score

Evidence levels A, B

Niacin, also known as nicotinamide or vitamin B3, is a critical nutrient incorporated into HAZEL's formulations for its wide-ranging health benefits, particularly in supporting metabolic health, enhancing skin condition, and promoting cardiovascular wellness. This essential vitamin plays a vital role in converting food into energy, contributing to the maintenance of healthy cells and improving cholesterol levels[24]. Furthermore, niacin has been extensively studied for its capacity to increase high-density lipoprotein (HDL) cholesterol, which helps reduce the risk of atherosclerosis and heart disease[25]. In addition to its cardiovascular benefits, niacin aids in skin health, offering protective effects against sun damage and improving skin barrier function[26]. HAZEL utilizes niacin in its products to leverage these health-promoting properties, ensuring our customers have access to a nutrient that supports not only metabolic and cardiovascular health but also contributes to maintaining a healthy, radiant complexion. Our commitment to incorporating scientifically backed ingredients like niacin underscores our dedication to delivering comprehensive wellness solutions.

[24]: Jacobson, T. A. (2010). "Niacin for reducing cardiovascular risk: Understanding the science and clinical considerations." American Journal of Cardiology, 106(5), 697–705. [Evidence Level: A] https://doi.org/10.1016/j.amjcard.2010.04.030

25]: Bruckert, E., et al. (2010). "An overview of the clinical pharmacology and therapeutic use of niacin for cardiovascular disease." British Journal of Clinical Pharmacology, 70(3), 308–316. [Evidence Level: A] https://doi.org/10.1111/j.1365-2125.2010.03720.x

[26]: Snaidr, V. A., et al. (2019). "Nicotinamide in dermatology: A capsule summary." International Journal of Dermatology, 58(12), 1359–1364. [Evidence Level: B] https://doi.org/10.1111/ijd.14624

Curcumin

from Tumeric

Score

Evidence level A

Curcumin, the active component of turmeric, is celebrated for its potent anti-inflammatory and antioxidant properties and is a cornerstone of HAZEL's Hazel Complex®. This compound has been extensively studied for its therapeutic potential in a wide range of diseases, including arthritis, anxiety, and high cholesterol[31]. Its effectiveness, however, is limited by its poor bioavailability, which is significantly enhanced by co-supplementation with bioenhancers like piperine[32]. Curcumin's ability to modulate several molecular targets underlines its systemic benefits, from reducing inflammation to protecting against oxidative stress. HAZEL leverages the synergistic effects of curcumin and piperine in Hazel Complex® to ensure that our customers receive the maximum health benefits, showcasing our commitment to providing innovative, science-backed wellness solutions.

[31]: Hewlings, S. J., & Kalman, D. S. (2017). "Curcumin: A Review of Its’ Effects on Human Health." Foods, 6(10), 92. [Evidence Level: A] https://doi.org/10.3390/foods6100092

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Piperine

from Piper Longum

Score

Evidence level B

Piperine, an alkaloid that gives black pepper its pungency, is strategically included in HAZEL's Hazel Complex® for its bioenhancing properties. This compound significantly improves the bioavailability of various nutrients, including curcumin, by inhibiting certain intestinal enzymes and enhancing intestinal absorption[29]. Scientific studies have demonstrated that piperine can increase the serum concentration of curcumin by up to 2000%, making it a critical component in maximizing the effectiveness of supplements[30]. Beyond its bioenhancement capabilities, piperine exhibits anti-inflammatory and antioxidant properties, contributing to overall health and wellness. By incorporating piperine, HAZEL ensures that the constituents of Hazel Complex® are more effectively absorbed and utilized by the body, enhancing the overall potency and efficacy of our health supplements.

[29]: Shoba, G., et al. (1998). "Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers." Planta Medica, 64(4), 353–356. [Evidence Level: B] https://doi.org/10.1055/s-2006-957450

[30]: Badmaev, V., et al. (1999). "Piperine derived from black pepper increases the plasma levels of coenzyme Q10 following oral supplementation." Journal of Nutritional Biochemistry, 10(2), 109–113. [Evidence Level: B] https://doi.org/10.1016/S0955-2863(98)00064-9

Shilajit

Mumijo, Asphaltum Punjabinum

Score

Evidence levels B, C

Shilajit, a key element in HAZEL's Hazel Complex®, is renowned not only for its intrinsic health benefits but also for its remarkable bioenhancing qualities, primarily attributed to its rich content of fulvic and humic acids. These organic acids are critical to shilajit's efficacy, significantly enhancing the bioavailability and action of nutrients and compounds within the body[33]. Fulvic acid, in particular, is celebrated for its ability to transport minerals and other nutrients into cells more efficiently, thereby improving nutrient absorption and maximizing the nutritional value of foods and supplements[34]. Moreover, fulvic and humic acids contribute to detoxification processes, binding to toxins and facilitating their removal from the body, which further optimizes cellular health and function.
The bioenhancing mechanism of fulvic and humic acids extends to improving the action of antioxidants, anti-inflammatory agents, and energy-producing compounds by enhancing cellular energy metabolism and nutrient assimilation. Their complex structure allows them to form a unique complex with minerals and vitamins, thereby enhancing the stability and bioavailability of these nutrients. Studies have illustrated that the combination of fulvic and humic acids in shilajit can lead to significant improvements in energy levels, overall vitality, and cognitive function, making these components invaluable in HAZEL's formulations[35].
By incorporating shilajit rich in fulvic and humic acids into the Hazel Complex®, HAZEL aims to not only deliver the direct benefits of these organic acids but also to amplify the efficacy of other health-promoting ingredients within our supplements. This strategic inclusion underscores our commitment to leveraging natural compounds for their potent bioenhancing effects, ensuring that our customers receive the most effective and holistic health solutions.

[33]: Carrasco-Gallardo, C., et al. (2012). "Shilajit: A natural phytocomplex with potential procognitive activity." International Journal of Alzheimer's Disease, 2012, 674142. [Evidence Level: B] https://doi.org/10.1155/2012/674142

[34]: Visser, S. A. (1987). "Effect of humic substances on mitochondrial respiration and oxidative phosphorylation." Science of the Total Environment, 62, 347–354. [Evidence Level: C] https://doi.org/10.1016/0048-9697(87)90505-3

[35]: Schepetkin, I. A., et al. (2003). "Immunomodulatory activity of fulvic acid from Shilajit." Phytomedicine, 10(6-7), 563–569. [Evidence Level: B] https://doi.org/10.1078/094471103322331520

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